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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T61743 | PPARγ agonist 2 | ||
PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ. It exhibits significant potential for utilization in metabolic disease research [1]. | |||
T28501 | Ragaglitazar | NNC61-0029,NN-622,(-)-DRF-2725,NNC-61-0029,NN 622,NNC 61-0029 | PPAR |
Ragaglitazar(NNC-61-0029) is a potent dual PPARα and PPARγ agonist that has shown potent lipid-lowering and insulin sensitizing effects in animal models.Ragaglitazar can be used to study type 2 diabetes. | |||
TN1475 | Caulophyllogenin | Segetalic acid | IL Receptor , TNF , PPAR , Immunology/Inflammation related |
Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammatory cytokine secretion and can be used in studies about the... | |||
T7796 | TUG-1375 | GPR | |
TUG-1375 is an Agonist of Thiazolidine Free Fatty Acid Receptor 2 | |||
T16022 | Arhalofenate | JNJ 39659100,MBX 102 | PPAR |
Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes. | |||
T21587 | Muraglitazar | Pargluva,BMS-298585 | PPAR |
Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r... | |||
T60184 | TUG-499 | GPR , PPAR | |
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA2, FFA3 and the nuclear receptor PPARγ, as well as other di... | |||
T6524 | GW0742 | GW610742 | PPAR |
GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ). | |||
T75690 | Wistin | ||
Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] . | |||
T61875 | Rivoglitazone | ||
Rivoglitazone is a thiazolidinedione-derivative PPARγ agonist for the treatment of type 2 diabetes mellitus. | |||
T15736 | Leriglitazone | Hydroxypioglitazone | Others |
Leriglitazone, a metabolite of pioglitazone, binds to the PPARγ C-terminal ligand-binding domain (Ki: 1.2 μM) and induces transcriptional efficacy of the PPARγ (EC50: 680 nM). Leriglitazone PioOH is a PPARγ agonist, stab... | |||
TMIH-0516 | Saroglitazar-d4 | ||
Saroglitazar-d4 is a deuterated compound of Saroglitazar. Saroglitazar has a CAS number of 495399-09-2. Saroglitazar is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ. | |||
T61836 | Pioglitazone potassium | ||
Pioglitazone potassium (U 72107) is an orally active and selective agonist of peroxisome proliferator-activated receptor gamma (PPARγ). It demonstrates high affinity binding to the ligand-binding domain of PPARγ, with an... | |||
TMIH-0517 | Saroglitazar oxide-d4 | ||
Saroglitazar oxide-d4 is a deuterated compound of Saroglitazar oxide. Saroglitazar oxide has a CAS number of 495399-09-2. Saroglitazar is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ. | |||
T61848 | Rosiglitazone potassium | ||
Rosiglitazone (BRL 49653) potassium is a potent and selective PPARγ agonist (EC 50: 60 nM, Kd: 40 nM), administered orally. It also serves as an activator of TRPC5 (EC 50: 30 μM) and an inhibitor of TRPM3. This compound,... | |||
T73842 | Leriglitazone hydrochloride | ||
Leriglitazone (Hydroxypioglitazone) hydrochloride, a pioglitazone metabolite, acts as a PPARγ agonist, effectively stabilizing the PPARγ activation function-2 (AF-2) co-activator binding surface to enhance co-activator b... | |||
T12876 | Seladelpar sodium salt | RWJ-800025 sodium salt,MBX-8025 sodium salt | Others |
Seladelpar sodium salt (MBX-8025) is an orally active, effective and specific PPARδ agonist with an EC 50 of 2 nM which exhibiting more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respecti... | |||
T37633 | 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid | ||
17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2... | |||
T64011 | GSK1820795A | ||
GSK1820795A, a telmisartan analog, functions as a selective antagonist of hGPR132a, inhibiting the activation of yeast cells that express hGPR132a by N-acylamides [1]. Additionally, it acts as an angiotensin II antagonis... | |||
T71306 | Gemfibrozil-d6 | ||
Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil redu... |